c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development.

doi:10.1093/molbev/msn165

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Article

c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development.

Molecular biology and evolution - 1 Oct 2008

Lin You-Chin, Kuo Ming-Wei, Yu John, Kuo Huan-Hsien, Lin Ruey-Jen, Lo Wan-Lin, Yu Alice L

Abstract excerpt

Human c-Myb proto-oncogene is highly expressed in hematopoietic progenitors as well as leukemia and certain solid tumor. However, the regulatory mechanisms of its expression and biological functions remain largely unclear. Recently, c-Myb has been shown to be targeted by microRNA-150 (miR-150) which thereby controls B cell differentiation in mice. In this study, we demonstrated that c-Myb is an evolutionary...

Topics

3' Untranslated Regions
Animals
Base Sequence
Cell Line, Tumor
Chromosome Aberrations
Evolution, Molecular
Gene Expression Regulation, Developmental
Humans
Lymphocytes
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MicroRNAs

Molecular Sequence Data

Phenotype

Proto-Oncogene Mas

Proto-Oncogene Proteins c-myb

Zebrafish

Source

Open in PubMed

Identifiers

PMID: 18667440
DOI: 10.1093/molbev/msn165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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