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Article

Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.

The Journal of biological chemistry - 16 Apr 2004

Nomura Teruaki, Tanikawa Jun, Akimaru Hiroshi, Kanei-Ishii Chie, Ichikawa-Iwata Emi, Khan Md Matiullah, Ito Hiroki, Ishii Shunsuke

Abstract excerpt

The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes. Removal or mutations of the negative regulatory domain (NRD) in the C-terminal half of c-Myb leads to increased transactivating capacity and oncogenic...

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Source

Identifiers

PMID: 14761981
DOI: 10.1074/jbc.M313069200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14761981-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.PMID 14761981Read ↗

Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.Semantic proximity Read ↗

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Mutations in multiple domains of c-Myb disrupt interaction with CBP/p300 and abrogate myeloid transforming ability.Semantic proximity Read ↗

Identification and Regulation of c-Myb Target Genes in MCF-7 CellsSemantic proximity Read ↗

Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription.Semantic proximity Read ↗

Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.Semantic proximity Read ↗

Dual Mechanism of Rag Gene Repression by c-Myb during Pre-B Cell Proliferation.Semantic proximity Read ↗

The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT.Semantic proximity Read ↗

A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability.Semantic proximity Read ↗

A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function.Semantic proximity Read ↗

Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1B β and TSLC1 in neuroblastomaSemantic proximity Read ↗

Transcriptional regulation by the carboxyl terminus of c-Myb depends upon both the Myb DNA-binding domain and the DNA recognition site.Semantic proximity Read ↗

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