Article
Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.
Oncogene - 2 Feb 2006
Liu F, Lei W, O'Rourke J P, Ness S A
Abstract excerpt
The v-Myb oncoprotein encoded by Avian Myeloblastosis Virus is highly oncogenic, induces leukemias in chickens and mice and transforms immature hematopoietic cells in vitro. The v-Myb protein is a mutated and truncated version of c-Myb, a DNA-binding transcription factor expressed in many cell types that is essential for normal hematopoiesis. Previous studies suggested that two types of differences, DNA binding...
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