Article
Mutations in multiple domains of c-Myb disrupt interaction with CBP/p300 and abrogate myeloid transforming ability.
Molecular cancer research : MCR - 1 Sept 2009
Pattabiraman Diwakar R, Sun Jane, Dowhan Dennis H, Ishii Shunsuke, Gonda Thomas J
Abstract excerpt
The c-myb proto-oncogene is a key regulator of hematopoietic cell proliferation and differentiation. MYB mRNA is expressed at high levels in, and is required for the proliferation of, most human myeloid and acute lymphoid leukemias. Recently, chromosomal translocation and genomic duplications of c-MYB have been identified in human T-cell acute leukemia. The present work focuses on the effects of mutations in...
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