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Article

Enhanced proliferative potential of hematopoietic cells expressing degradation-resistant c-Myb mutants.

The Journal of biological chemistry - 26 Aug 2005

Corradini Francesca, Cesi Vincenzo, Bartella Viviana, Pani Elisabetta, Bussolari Rita, Candini Olivia, Calabretta Bruno

Abstract excerpt

The c-myb gene encodes a transcription factor required for proliferation, differentiation, and survival of hematopoietic cells. Expression of c-Myb is often increased in hematological malignancies, but the underlying mechanisms are poorly understood. We show here that c-Myb has a longer half-life (at least 2-fold) in BCR/ABL-expressing than in normal hematopoietic cells. Such enhanced stability was dependent on a...

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Identifiers

PMID: 15927960
DOI: 10.1074/jbc.M504703200

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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