Article
Gender- and age-specific contributions of additional DNA sequence variation in the 5' regulatory region of the APOE gene to prediction of measures of lipid metabolism.
Human genetics - 1 Sept 2004
Frikke-Schmidt Ruth, Sing Charles F, Nordestgaard Børge G, Tybjaerg-Hansen Anne
Abstract excerpt
In the present study of 9,000 individuals representative of the general population, we have considered whether the addition of common single nucleotide polymorphisms (SNPs) in the promoter region of Apolipoprotein E (APOE) improve the statistical explanation of variation in lipid traits and test the hypothesis that the estimated genotype effects are independent of factors indexed by gender and age. To address...
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