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Article

Evidence for non-additive influence of single nucleotide polymorphisms within the apolipoprotein E gene.

Annals of human genetics - 1 Nov 2004

Hamon S C, Stengard J H, Clark A G, Salomaa V, Boerwinkle E, Sing C F

Abstract excerpt

We analyzed 13 single nucleotide polymorphisms (SNPs) within the apolipoprotein E (APOE) gene, to identify pairs of SNPs that interact in a non-additive manner to influence genotypic mean levels of the ApoE protein in blood. An overparameterized general linear model of two-SNP genotype means was applied to data from 456 female and 398 male unrelated European Americans from Rochester, MN, USA. We found...

Topics

Apolipoproteins E
Female
Genotype
Humans
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15598211
DOI: 10.1046/j.1529-8817.2003.00112.x

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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