Article
Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene.
Human mutation - 1 Jul 2009
Fritsche Lars G, Freitag-Wolf Sandra, Bettecken Thomas, Meitinger Thomas, Keilhauer Claudia N, Krawczak Michael, Weber Bernhard H F
Abstract excerpt
Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing) and E4 (protective). The biological correlate of this association, however, is still unclear. In this study, we have...
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