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Article

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

Aging - 1 Aug 2016

Noordam Raymond, Oudt Charlotte H, Deelen Joris, Slagboom P Eline, Beekman Marian, van Heemst Diana

Abstract excerpt

Offspring of long-lived families are characterized by beneficial metabolic phenotypes in glucose and lipid metabolism and low 25-hydroxyvitamin D. Although the genetic basis for human longevity remains largely unclear, the contribution of variation at the APOE locus has been repeatedly demonstrated. We aimed to assess whether ApoE isoforms mark the familial longevity status in middle age and subsequently to test...

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Identifiers

PMID: 27540764
DOI: 10.18632/aging.101017
PMCID: PMC5032696

Genes

APOE

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