Article
Contribution of regulatory and structural variations in APOE to predicting dyslipidemia.
Journal of lipid research - 1 Feb 2006
Stengård Jari H, Kardia Sharon L R, Hamon Sara C, Frikke-Schmidt Ruth, Tybjaerg-Hansen Anne, Salomaa Veikko, Boerwinkle Eric, Sing Charles F
Abstract excerpt
The objective of this study was to evaluate 1) whether non single nucleotide polymorphisms-coding (non-cSNP) in the apolipoprotein E gene (APOE) identified by resequencing studies contribute to statistically explaining dyslipidemia if variations in the two cSNPs in exon 4 that define the 2, 3, and 4 alleles are ignored, and 2) whether the contribution of these additional SNPs persists when variations in the cSNPs...
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