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Article

Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

PloS one - 2 Apr 2010

Drenos Fotios, Kirkwood Thomas B L

Abstract excerpt

It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors (gender, diet, smoking, alcohol, exercise) that, because there is a statistical distribution of ages at which these genes exert their influence on morbidity and...

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Identifiers

PMID: 20368805
DOI: 10.1371/journal.pone.0010022
PMCID: PMC2848859

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