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Article

Lack of association between sigma receptor gene variants and schizophrenia.

Psychiatry and clinical neurosciences - 1 Aug 2004

Satoh Fumiaki, Miyatake Ryosuke, Furukawa Aizo, Suwaki Hiroshi

Abstract excerpt

Several pharmacological studies suggest the possible involvement of sigma(1) receptors in the pathogenesis of schizophrenia. An association has been reported between schizophrenia and two variants (GC-241-240TT and Gln2Pro) in the sigma(1) receptor gene (SIGMAR1). We also previously reported that, along with T-485 A, these two variants alter SIGMAR1 function. To investigate the role of SIGMAR1 in conveying...

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Source

Identifiers

PMID: 15298647
DOI: 10.1111/j.1440-1819.2004.01268.x

Genes

SIGMAR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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