Article
Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia.
Neuroscience letters - 20 Nov 1998
Ishiguro H, Ohtsuki T, Toru M, Itokawa M, Aoki J, Shibuya H, Kurumaji A, Okubo Y, Iwawaki A, Ota K, Shimizu H, Hamaguchi H, Arinami T
Abstract excerpt
Several antipsychotic agents such as haloperidol and rimcazole are known to bind to sigma receptors with high affinity, and evidence for a potential link between sigma receptors and the etiology of schizophrenia has been reported. The present study was conducted to systematically search for nucle...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- DNA Primers
- Female
- Gene Frequency
- Genetic Linkage
- Glutamine
- Humans
- Japan
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Proline
- Receptors, sigma