Article
The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex.
Progress in neuro-psychopharmacology & biological psychiatry - 1 Jul 2011
Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Umeda-Yano Satomi, Kamino Kouzin, Ikezawa Koji, Azechi Michiyo, Iwase Masao, Kazui Hiroaki, Kasai Kiyoto, Takeda Masatoshi
Abstract excerpt
Several studies have identified the possible involvement of sigma non-opioid intracellular receptor 1 (SIGMAR1) in the pathogenesis of schizophrenia. The Gln2Pro polymorphism in the SIGMAR1 gene has been extensively examined for an association with schizophrenia. However, findings across multiple studies have been inconsistent. We performed a meta-analysis of the association between the functional Gln2Pro...
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