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Article

Functional polymorphisms in the sigma1 receptor gene associated with alcoholism.

Biological psychiatry - 1 Jan 2004

Miyatake Ryosuke, Furukawa Aizo, Matsushita Sachio, Higuchi Susumu, Suwaki Hiroshi

Abstract excerpt

BACKGROUND: Sigma1 receptors are involved in the pathogenesis of drug abuse. Two polymorphisms (GC-241-240TT and Gln2Pro) in the sigma1 receptor gene (SIGMAR1) have been identified. To investigate the role of SIGMAR1 in conveying susceptibility to alcoholism, we performed a functional analysis of polymorphisms in the SIGMAR1 and a case-control study. METHODS: We initially screened for polymorphisms in the...

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Source

Identifiers

PMID: 14706429
DOI: 10.1016/j.biopsych.2003.07.008

Genes

SIGMAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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