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Article

A variant of the sigma receptor type-1 gene is a protective factor for Alzheimer disease.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Dec 2005

Uchida Naohiko, Ujike Hiroshi, Tanaka Yuji, Sakai Ayumu, Yamamoto Mitsutoshi, Fujisawa Yoshikatsu, Kanzaki Akihiro, Kuroda Shigetoshi

Abstract excerpt

OBJECTIVE: Some preclinical evidence suggests that the sigma receptor type 1, which plays several roles in learning and memory, may also be involved in the pathogenesis of Alzheimer disease (AD). The authors provide here genetic evidence that the sigma receptor type 1 (SIGMAR1) gene is involved i...

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Source

Identifiers

PMID: 16319298
DOI: 10.1176/appi.ajgp.13.12.1062

Genes

SIGMAR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16319298-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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