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Article

Sigma receptor type 1 gene variation in a group of Polish patients with Alzheimer's disease and mild cognitive impairment.

Dementia and geriatric cognitive disorders - 1 Jan 2007

Maruszak Aleksandra, Safranow Krzysztof, Gacia Magdalena, Gabryelewicz Tomasz, Słowik Agnieszka, Styczyńska Maria, Pepłońska Beata, Golan Maciej P, Zekanowski Cezary, Barcikowska Maria

Abstract excerpt

The sigma-1 receptor (SIGMAR1) is a subtype of a nonopioid sigma receptor family and is implicated in numerous functions connected with Alzheimer's disease (AD). Two common genetic variants were identified in SIGMAR1: GC-241 -240TT and Q2P (A61C). It was suggested that the TT-C haplotype is a protective factor for AD. We decided to investigate a putative link between the variants of SIGMAR1 and AD in a group of...

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Identifiers

PMID: 17457031
DOI: 10.1159/000101990

Genes

SIGMAR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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