Article
No association between a promoter dopamine D(4) receptor gene variant and schizophrenia.
American journal of medical genetics - 8 Aug 2001
Jönsson E G, Ivo R, Forslund K, Mattila-Evenden M, Rylander G, Cichon S, Propping P, Nöthen M M, Asberg M, Sedvall G C
Abstract excerpt
The dopamine D(4) receptor has been implicated in the pathogenesis of schizophrenia. An association between a putative functional promoter polymorphism (-521C/T) in the dopamine D(4) receptor gene (DRD4) and schizophrenia was recently reported. In the present study, patients with schizophrenia (n = 132) and control subjects (n = 388) were analyzed with respect to the DRD4 - 521C/T polymorphism. No significant...
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