No association between a promoter dopamine D(4) receptor gene variant and schizophrenia.

doi:10.1002/ajmg.1478

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Article

No association between a promoter dopamine D(4) receptor gene variant and schizophrenia.

American journal of medical genetics - 8 Aug 2001

Jönsson E G, Ivo R, Forslund K, Mattila-Evenden M, Rylander G, Cichon S, Propping P, Nöthen M M, Asberg M, Sedvall G C

Abstract excerpt

The dopamine D(4) receptor has been implicated in the pathogenesis of schizophrenia. An association between a putative functional promoter polymorphism (-521C/T) in the dopamine D(4) receptor gene (DRD4) and schizophrenia was recently reported. In the present study, patients with schizophrenia (n = 132) and control subjects (n = 388) were analyzed with respect to the DRD4 - 521C/T polymorphism. No significant...

Topics

Adult
Alleles
DNA
Female
Gene Frequency
Genetic Variation
Genotype
Humans
Male
Middle Aged
Promoter Regions, Genetic
Receptors, Dopamine D2
Receptors, Dopamine D4
Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 11496369
DOI: 10.1002/ajmg.1478

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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