Article
On the slowing of S phase in response to DNA damage in fission yeast.
The Journal of biological chemistry - 15 Oct 2004
Kumar Sanjay, Huberman Joel A
Abstract excerpt
Eukaryotic cells slow their progression through S phase upon DNA damage. The mechanism that leads to this slowing is called the intra-S-phase checkpoint. Previous studies demonstrated that in the fission yeast Schizosaccharomyces pombe this checkpoint is mediated by a pathway that includes Rad3 (similar to human ATR and ATM) and Cds1 (similar to human Chk1 and Chk2). Here we present evidence that a major...
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