Article
Induction of a G1-S checkpoint in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2012
Bøe Cathrine A, Krohn Marit, Rødland Gro Elise, Capiaghi Christoph, Maillard Olivier, Thoma Fritz, Boye Erik, Grallert Beáta
Abstract excerpt
Entry into S phase is carefully regulated and, in most organisms, under the control of a G(1)-S checkpoint. We have previously described a G(1)-S checkpoint in fission yeast that delays formation of the prereplicative complex at chromosomal replication origins after exposure to UV light (UVC). This checkpoint absolutely depends on the Gcn2 kinase. Here, we explore the signal for activation of the Gcn2-dependent...
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