Article
MRX (Mre11/Rad50/Xrs2) mutants reveal dual intra-S-phase checkpoint systems in budding yeast.
Cell cycle (Georgetown, Tex.) - 1 Aug 2005
Andrews Catherine A, Clarke Duncan J
Abstract excerpt
The intra-S-phase checkpoint is a signaling pathway that induces slow DNA replication in the presence of DNA damage. In humans, defects in this checkpoint pathway might account for phenotypes seen in autosomal recessive diseases including ataxia telangiectasia-like disorder and Nijmegen breakage syndrome, where MRN complex components,Mre11 and Nbs1, are mutated. Here we provide evidence that the equivalent...
Topics
- Bleomycin
- Cell Cycle
- Cell Cycle Proteins
- Cell Separation
- Checkpoint Kinase 2
- Chromosomal Proteins, Non-Histone
- DNA Damage
- DNA Repair
- DNA Replication
- DNA, Fungal
- DNA-Binding Proteins