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The G2 DNA damage checkpoint: Could this ancient regulator be the Achilles heel of cancer?

1 Aug 2009

Abstract excerpt

The maintenance of genomic integrity is important in normal cell growth and organism development, as well as in the prevention of cancer. Cell cycle checkpoints allow the cell time to complete replication and repair DNA damage before it can pass to the next cell cycle stage. These checkpoints ensure faithful segregation of one undamaged copy of the genome to each daughter cell. In humans, a DNA damage-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19574738
DOI: 10.4161/cbt.8.15.9081

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