14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.

doi:10.1126/science.8036497

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Article

14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.

Science (New York, N.Y.) - 22 Jul 1994

Ford J C, al-Khodairy F, Fotou E, Sheldrick K S, Griffiths D J, Carr A M

Abstract excerpt

During the cell cycle, DNA is replicated and segregated equally into two daughter cells. The DNA damage checkpoint ensures that DNA damage is repaired before mitosis is attempted. Genetic studies of the fission yeast Schizosaccharomyces pombe have identified two genes, rad24 and rad25, that are required for this checkpoint. These genes encode 14-3-3 protein homologs that together provide a function that is...

Topics

14-3-3 Proteins
Amino Acid Sequence
Cell Cycle Proteins
Cell Division
DNA Damage
DNA Helicases
DNA Repair
Fungal Proteins
Genes, Fungal
Intracellular Signaling Peptides and Proteins
Mitosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Nerve Tissue Proteins

Phenotype

Schizosaccharomyces

Schizosaccharomyces pombe Proteins

Sequence Alignment

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 8036497
DOI: 10.1126/science.8036497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8036497-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.PMID 8036497Read ↗

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