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Article

14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.

Science (New York, N.Y.) - 22 Jul 1994

Ford J C, al-Khodairy F, Fotou E, Sheldrick K S, Griffiths D J, Carr A M

Abstract excerpt

During the cell cycle, DNA is replicated and segregated equally into two daughter cells. The DNA damage checkpoint ensures that DNA damage is repaired before mitosis is attempted. Genetic studies of the fission yeast Schizosaccharomyces pombe have identified two genes, rad24 and rad25, that are required for this checkpoint. These genes encode 14-3-3 protein homologs that together provide a function that is...

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Identifiers

PMID: 8036497
DOI: 10.1126/science.8036497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.PMID 8036497Read ↗

Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity.Semantic proximity Read ↗

Cdc25B activity is regulated by 14-3-3.Semantic proximity Read ↗

Fission yeast F-box protein Pof3 is required for genome integrity and telomere function.Semantic proximity Read ↗

A screen for Schizosaccharomyces pombe mutants defective in rereplication identifies new alleles of rad4+, cut9+ and psf2+.Semantic proximity Read ↗

Isolation and characterization of the Schizosaccharomyces pombe rad3 gene, involved in the DNA damage and DNA synthesis checkpoints.Semantic proximity Read ↗

The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage.Semantic proximity Read ↗

Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.Semantic proximity Read ↗

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.Semantic proximity Read ↗

DNA damage and cell cycle checkpointsSemantic proximity Read ↗

A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2.Semantic proximity Read ↗

Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.Semantic proximity Read ↗

The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division.Semantic proximity Read ↗

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