Article
A mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin.
Genes & development - 1 May 2006
Andrews Catherine A, Vas Amit C, Meier Brian, Giménez-Abián Juan F, Díaz-Martínez Laura A, Green Julie, Erickson Stacy L, Vanderwaal Kristyn E, Hsu Wei-Shan, Clarke Duncan J
Abstract excerpt
Topoisomerase II (Topo II) performs topological modifications on double-stranded DNA molecules that are essential for chromosome condensation, resolution, and segregation. In mammals, G2 and metaphase cell cycle delays induced by Topo II poisons have been proposed to be the result of checkpoint activation in response to the catenation state of DNA. However, the apparent lack of such controls in model organisms...
Topics
- Anaphase-Promoting Complex-Cyclosome
- Cell Cycle Proteins
- Chromosomes, Fungal
- DNA Damage
- DNA Topoisomerases, Type II
- Endopeptidases
- G2 Phase
- Genomic Instability
- Mitosis
- Mutation
- Nuclear Proteins
- Protein-Tyrosine Kinases