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Article

Mutations in the central polypurine tract of HIV-1 result in delayed replication.

Virology - 1 Sept 1992

Hungnes O, Tjøtta E, Grinde B

Abstract excerpt

The reverse transcription of HIV-1 generates a linear genomic DNA with a single-stranded gap. The gap is believed to be the result of plus-strand priming from a second, centrally located, polypurine tract (PPT). A mutant containing four amino-acid-neutral purine-to-pyrimidine changes within the central PPT did not replicate as fast as wild-type virus. Another mutant with the entire 15-bp PPT deleted was...

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Identifiers

PMID: 1529543
DOI: 10.1016/0042-6822(92)91230-r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the central polypurine tract of HIV-1 result in delayed replication.PMID 1529543Read ↗

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