Mutations in the central polypurine tract of HIV-1 result in delayed replication.

doi:10.1016/0042-6822(92)91230-r

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Article

Mutations in the central polypurine tract of HIV-1 result in delayed replication.

Virology - 1 Sept 1992

Hungnes O, Tjøtta E, Grinde B

Abstract excerpt

The reverse transcription of HIV-1 generates a linear genomic DNA with a single-stranded gap. The gap is believed to be the result of plus-strand priming from a second, centrally located, polypurine tract (PPT). A mutant containing four amino-acid-neutral purine-to-pyrimidine changes within the c...

Topics

Base Sequence
DNA, Viral
HIV-1
Kinetics
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Purines
Virus Replication

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