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Article

Selection of optimal polypurine tract region sequences during Moloney murine leukemia virus replication.

Journal of virology - 1 Nov 2000

Robson N D, Telesnitsky A

Abstract excerpt

Retrovirus plus-strand synthesis is primed by a cleavage remnant of the polypurine tract (PPT) region of viral RNA. In this study, we tested replication properties for Moloney murine leukemia viruses with targeted mutations in the PPT and in conserved sequences upstream, as well as for pools of mutants with randomized sequences in these regions. The importance of maintaining some purine residues within the PPT...

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Identifiers

PMID: 11044073
DOI: 10.1128/jvi.74.22.10293-10303.2000
PMCID: PMC110903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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