A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication.

doi:10.1128/JVI.66.5.2814-2820.1992

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Article

A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication.

Journal of virology - 1 May 1992

Charneau P, Alizon M, Clavel F

Abstract excerpt

We recently reported that human immunodeficiency virus type 1 (HIV-1) unintegrated linear DNA displays a discontinuity in its plus strand, precisely defined by a second copy of the polypurine tract (PPT) located near the middle of the genome (P. Charneau and F. Clavel, J. Virol. 65:2415-2421, 1991). This central PPT appears to determine a second initiation site for retrovirus DNA plus-strand synthesis. We show...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Base Sequence
DNA Mutational Analysis
DNA Nucleotidyltransferases
DNA Replication
DNA, Viral
Genes, pol
HIV-1
Humans
Integrases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis, Site-Directed

Phenotype

Purines

Regulatory Sequences, Nucleic Acid

Virus Integration

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 1560526
DOI: 10.1128/JVI.66.5.2814-2820.1992
PMCID: PMC241038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1560526-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A second origin of DNA plus-strand synthesis is required for optimal human immunodeficiency virus replication.PMID 1560526Read ↗

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