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Article

Effect of polypurine tract (PPT) mutations on human immunodeficiency virus type 1 replication: a virus with a completely randomized PPT retains low infectivity.

Journal of virology - 1 Jun 2005

Miles Lesa R, Agresta Beth E, Khan Mahfuz B, Tang Shixing, Levin Judith G, Powell Michael D

Abstract excerpt

We introduced polypurine tract (PPT) mutations, which we had previously tested in an in vitro assay, into the viral clone NL4-3KFSdelta nef. Each mutant was tested for single-round infectivity and virion production. All of the PPT mutations had an effect on replication; however, mutation of the 5' end appeared to have less of an effect on infectivity than mutation of the 3' end of the PPT sequence. Curiously, a...

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Identifiers

PMID: 15890925
DOI: 10.1128/JVI.79.11.6859-6867.2005
PMCID: PMC1112125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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