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Article

SiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.

PloS one - 1 Jan 2015

Rausch Jason W, Tian Meijuan, Li Yuejin, Angelova Lora, Bagaya Bernard S, Krebs Kendall C, Qian Feng, Zhu Chuanwu, Arts Eric J, Le Grice Stuart F J, Gao Yong

Abstract excerpt

Converting single-stranded viral RNA into double stranded DNA for integration is an essential step in HIV-1 replication. Initial polymerization of minus-strand DNA is primed from a host derived tRNA, whereas subsequent plus-strand synthesis requires viral primers derived from the 3' and central polypurine tracts (3' and cPPTs). The 5' and 3' termini of these conserved RNA sequence elements are precisely cleaved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25860884
DOI: 10.1371/journal.pone.0122953
PMCID: PMC4393142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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