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Article

Effects of 3' untranslated region mutations on plus-strand priming during moloney murine leukemia virus replication.

Journal of virology - 1 Feb 1999

Robson N D, Telesnitsky A

Abstract excerpt

A conserved purine-rich motif located near the 3' end of retroviral genomes is involved in the initiation of plus-strand DNA synthesis. We mutated sequences both within and flanking the Moloney murine leukemia virus polypurine tract (PPT) and determined the effects of these alterations on viral DNA synthesis and replication. Our results demonstrated that both changes in highly conserved PPT positions and a...

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Identifiers

PMID: 9882295
DOI: 10.1128/JVI.73.2.948-957.1999
PMCID: PMC103914

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Source receipt: pubmed, retrieved 7 Sept 2026.

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