Effects of 3' untranslated region mutations on plus-strand priming during moloney murine leukemia virus replication.

doi:10.1128/JVI.73.2.948-957.1999

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Article

Effects of 3' untranslated region mutations on plus-strand priming during moloney murine leukemia virus replication.

Journal of virology - 1 Feb 1999

Robson N D, Telesnitsky A

Abstract excerpt

A conserved purine-rich motif located near the 3' end of retroviral genomes is involved in the initiation of plus-strand DNA synthesis. We mutated sequences both within and flanking the Moloney murine leukemia virus polypurine tract (PPT) and determined the effects of these alterations on viral D...

Topics

3' Untranslated Regions
3T3 Cells
Animals
Base Sequence
Cell Line
DNA, Viral
Genetic Vectors
Humans
Mice
Molecular Sequence Data
Moloney murine leukemia virus
Mutation
Proviruses
Virus Replication

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