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Article

The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptase.

The Journal of biological chemistry - 25 Mar 1993

Pullen K A, Rattray A J, Champoux J J

Abstract excerpt

A specific cleavage by the reverse transcriptase-associated RNase H activity generates the RNA primer for plus strand DNA synthesis during reverse transcription. Previously, we used site-directed mutagenesis to define the sequence features of the polypurine tract (PPT) required for correct plus strand priming by the Moloney murine leukemia virus (M-MuLV) reverse transcriptase (Rattray, A. J., and Champoux, J. J....

Topics

Base Sequence
DNA, Viral
HIV Reverse Transcriptase
HIV-1
Molecular Sequence Data
Moloney murine leukemia virus
Mutation
Purines
RNA-Directed DNA Polymerase
Substrate Specificity

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PMID: 7681062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7681062-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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