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Article

The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.

Journal of virology - 1 Nov 2010

Hu Chunling, Saenz Dyana T, Fadel Hind J, Walker William, Peretz Mary, Poeschla Eric M

Abstract excerpt

HIV-1 and certain other retroviruses initiate plus-strand synthesis in the center of the genome as well as at the standard retroviral 3' polypurine tract. This peculiarity of reverse transcription results in a central DNA "flap" structure that has been of controversial functional significance. We mutated both HIV-1 flap-generating elements, the central polypurine tract (cPPT) and the central termination sequence...

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Identifiers

PMID: 20844042
DOI: 10.1128/JVI.00723-10
PMCID: PMC2977901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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