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Article

Pre-existing distortions in nucleic acid structure aid polypurine tract selection by HIV-1 reverse transcriptase.

The Journal of biological chemistry - 10 May 2002

Kvaratskhelia Mamuka, Budihas Scott R, Le Grice Stuart F J

Abstract excerpt

Precise cleavage at the polypurine tract (PPT)/U3 junction by human immunodeficiency virus type 1 (HIV-1) reverse transcriptase RNase H is critical for generating a correct viral DNA end for subsequent integration. Using potassium permanganate (KMnO(4)) modification, we have identified a significant distortion in the nucleic acid structure at the HIV-1 PPT/U3 junction in the absence of trans-acting factors....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11875059
DOI: 10.1074/jbc.M109914200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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