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Article

Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein.

Journal of the American Society of Nephrology : JASN - 1 Aug 2004

Zhang Guoqiang, Cai Xiaohe, López-Guisa Jesús M, Collins Sarah J, Eddy Allison A

Abstract excerpt

The urokinase receptor (uPAR) attenuates myofibroblast recruitment and fibrosis in the kidney. This study examined the role of uPAR and its co-receptor LDL receptor-related protein (LRP) in the regulation of kidney fibroblast proliferation and extracellular signal-regulated kinase (ERK) signaling. Compared with uPAR+/+ cells, uPAR-/- kidney fibroblasts were hyperproliferative. UPAR-/- fibroblast proliferation was...

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Share to Plasminogen Activator Inhibitor 1

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PMID: 15284295
DOI: 10.1097/01.ASN.0000135057.41526.2C

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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