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Article

Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy.

Journal of the American Society of Nephrology : JASN - 1 May 2003

Zhang Guoqiang, Kim Heungsoo, Cai Xiaohe, Lopez-Guisa Jesus M, Carmeliet Peter, Eddy Allison A

Abstract excerpt

Interstitial cells have been implicated in the pathogenesis of renal fibrosis. Given that the urokinase receptor (uPAR) is known to play a role in cell adhesion, migration, and angiogenesis, the present study was designed to evaluate the role of uPAR in the regulation of the phenotypic composition of interstitial cells (macrophages, myofibroblasts, capillaries) in response to chronic renal injury. Groups of uPAR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Physiologic

Share to Plasminogen Activator Inhibitor 1

Share to Receptors, Urokinase Plasminogen Activator

Share to Ureteral Obstruction

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Source

Identifiers

PMID: 12707393
DOI: 10.1097/01.asn.0000064701.70231.3f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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