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Article

Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator.

The Journal of biological chemistry - 29 Apr 2005

Jo Minji, Thomas Keena S, Marozkina Nadzeya, Amin Tanay J, Silva Corinne M, Parsons Sarah J, Gonias Steven L

Abstract excerpt

The urokinase-type plasminogen activator (uPA) receptor (uPAR) functions in concert with co-receptors, including integrins, FPR-like receptor-1/lipoxin A4 receptor, and the epidermal growth factor receptor (EGFR), to initiate cell signaling. uPAR co-receptors may be dynamically organized into a multiprotein signaling receptor complex. In Chinese hamster ovary-K1 (CHO-K1) cells, uPA-binding to uPAR activates...

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PMID: 15728176
DOI: 10.1074/jbc.M413141200

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EGFR

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