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Article

Urokinase receptor associates with myocardin to control vascular smooth muscle cells phenotype in vascular disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2012

Kiyan Yulia, Limbourg Anne, Kiyan Roman, Tkachuk Sergey, Limbourg Florian P, Ovsianikov Aleksandr, Chichkov Boris N, Haller Hermann, Dumler Inna

Abstract excerpt

OBJECTIVE: The urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR) are a potent multifunctional system involved in vascular remodeling. The goal of the study was to unravel the mechanisms of uPA/uPAR-directed vascular smooth muscle cell (VSMC) differentiation. METHODS AND RESULTS: Using cultured human primary VSMCs, we identified a new molecular mechanism controlling phenotypic modulation...

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Identifiers

PMID: 22075245
DOI: 10.1161/ATVBAHA.111.234369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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