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Article

Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy.

Journal of the American Society of Nephrology : JASN - 1 May 2003

Zhang Guoqiang, Kim Heungsoo, Cai Xiaohe, López-Guisa Jesús M, Alpers Charles E, Liu Youhua, Carmeliet Peter, Eddy Allison A

Abstract excerpt

The urokinase cellular receptor (uPAR) recognizes the N-terminal growth factor domain of urokinase-type plasminogen activator (uPA) and is expressed by several cell types. The present study was designed to test the hypothesis that uPAR regulates the renal fibrogenic response to chronic injury. Groups of uPAR wild-type (+/+) and deficient (-/-) mice were investigated between 3 and 14 d after unilateral ureteral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12707394
DOI: 10.1097/01.asn.0000064292.37793.fb

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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