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Article

Urokinase plasminogen activator induces pro-fibrotic/m2 phenotype in murine cardiac macrophages.

PloS one - 1 Jan 2013

Meznarich Jessica, Malchodi Laura, Helterline Deri, Ramsey Stephen A, Bertko Kate, Plummer Tabitha, Plawman Abigail, Gold Elizabeth, Stempien-Otero April

Abstract excerpt

OBJECTIVE: Inflammation and fibrosis are intertwined in multiple disease processes. We have previously found that over-expression of urokinase plasminogen activator in macrophages induces spontaneous macrophage accumulation and fibrosis specific to the heart in mice. Understanding the relationship between inflammation and fibrosis in the heart is critical to developing therapies for diverse myocardial diseases....

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Identifiers

PMID: 23536772
DOI: 10.1371/journal.pone.0057837
PMCID: PMC3594198

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