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Article

Endogenous urokinase lacks antifibrotic activity during progressive renal injury.

American journal of physiology. Renal physiology - 1 Jul 2007

Yamaguchi Ikuyo, Lopez-Guisa Jesus M, Cai Xiaohe, Collins Sarah J, Okamura Daryl M, Eddy Allison A

Abstract excerpt

Interstitial fibrosis is a universal feature of progressive kidney disease. Urokinase-type plasminogen activator (uPA) is thought to participate for several reasons: 1) uPA is produced predominantly in kidney, 2) its inhibitor plasminogen activator inhibitor-1 (PAI-1) is a strong promoter of interstitial fibrosis, whereas its receptor (uPAR) attenuates renal fibrosis, 3) uPA reduces fibrosis in liver and lung,...

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Source

Identifiers

PMID: 17356128
DOI: 10.1152/ajprenal.00380.2006

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HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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