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Article

Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.

Kidney international - 1 Jun 2005

Matsuo Shunya, López-Guisa Jesús M, Cai Xiaohe, Okamura Daryl M, Alpers Charles E, Bumgarner Roger E, Peters Mette A, Zhang Guoqiang, Eddy Allison A

Abstract excerpt

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) has been implicated in the pathogenesis of chronic kidney disease based on its up-regulated expression and on the beneficial effects of PAI-1 inhibition or depletion in experimental models. PAI-1 is a multifunctional protein and the mechanisms that account for its profibrotic effects have not been fully elucidated. METHODS: The present study was designed to...

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Identifiers

PMID: 15882265
DOI: 10.1111/j.1523-1755.2005.00327.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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