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Article

The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP.

The Journal of biological chemistry - 24 Sept 2004

Shapiro Michael J, Powell Penda, Ndubuizu Adanma, Nzerem Chima, Shapiro Virginia Smith

Abstract excerpt

Activation of naive T cells occurs when two signals are received. The first signal is received through the T cell antigen receptor (TCR), and a second costimulatory signal is primarily provided by CD28. We have recently identified a novel adaptor molecule, ALX, which is expressed exclusively in hematopoietic cells. ALX contains several sites for potential protein-protein interaction, including an Src homology 2...

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Identifiers

PMID: 15284240
DOI: 10.1074/jbc.M404198200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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