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Article

The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease.

Nature reviews. Immunology - 1 Oct 2003

Engel Pablo, Eck Michael J, Terhorst Cox

Abstract excerpt

SAP (signalling lymphocytic activation molecule (SLAM)-associated protein) is a T- and natural killer (NK)-cell-specific protein containing a single SH2 domain encoded by a gene that is defective or absent in patients with X-linked lymphoproliferative syndrome (XLP). The SH2 domain of SAP binds w...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14523387
DOI: 10.1038/nri1202

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14523387-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease.PMID 14523387Read ↗

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Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.Semantic proximity Read ↗

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Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462-469.Semantic proximity Read ↗

Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAPSemantic proximity Read ↗

Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.Semantic proximity Read ↗

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X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.Semantic proximity Read ↗

SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients.Semantic proximity Read ↗

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