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Article

The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation.

The Journal of biological chemistry - 18 Nov 2005

Shapiro Michael J, Chen Yen-Yu, Shapiro Virginia Smith

Abstract excerpt

The adaptor protein ALX acts downstream of CD28 to regulate the interleukin-2 (IL-2) promoter during T cell activation. Whereas ALX is predominantly localized to the cytoplasm, ALX partially resides in the nucleus, and the nuclear pool is rapidly depleted in response to T cell receptor (TCR)/CD28 signaling. Here it is shown that this depletion occurs via nuclear export of ALX, which depends on a leucine-rich...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16169852
DOI: 10.1074/jbc.M507441200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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