Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cloning and characterization of ALX, an adaptor downstream of CD28.

The Journal of biological chemistry - 14 Nov 2003

Greene Tiffani A, Powell Penda, Nzerem Chima, Shapiro Michael J, Shapiro Virginia Smith

Abstract excerpt

T cell activation requires two signals: specific recognition of antigen through the T cell receptor (TCR) and a costimulatory signal provided primarily by CD28 in naïve T cells. We cloned a novel gene with considerable homology to RIBP/TSAd/Lad, an adaptor involved in T cell activation and interleukin-2 (IL-2) promoter activation. Expression of this gene is limited to the spleen and thymus. We have named this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD28 Antigens
Share to Interleukin-2
Share to Jurkat Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Spleen

Share to Tetradecanoylphorbol Acetate

Share to Thymus Gland

Share to Tissue Distribution

Source

Identifiers

PMID: 12960172
DOI: 10.1074/jbc.M306283200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cloning and characterization of ALX, an adaptor downstream of CD28.PMID 12960172Read ↗

The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP.Semantic proximity Read ↗

The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation.Semantic proximity Read ↗

The adapter proteins LAT and SLP-76 are required for T-cell activation.Semantic proximity Read ↗

AP ‐1 is involved in ICOS gene expression downstream of TCR / CD 28 and cytokine receptor signalingSemantic proximity Read ↗

Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.Semantic proximity Read ↗

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.Semantic proximity Read ↗

The adaptor protein LAD/TSAd mediates laminin-dependent T cell migration via association with the 67 kDa laminin binding protein.Semantic proximity Read ↗

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T CellsSemantic proximity Read ↗

The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.Semantic proximity Read ↗

Activation of T lymphocytes and the role of the adapter LAT.Semantic proximity Read ↗

Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAPSemantic proximity Read ↗

The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.