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Article

SH2 domains: modulators of nonreceptor tyrosine kinase activity.

Current opinion in structural biology - 1 Dec 2009

Filippakopoulos Panagis, Müller Susanne, Knapp Stefan

Abstract excerpt

The Src homology 2 (SH2) domain is a sequence-specific phosphotyrosine-binding module present in many signaling molecules. In cytoplasmic tyrosine kinases, the SH2 domain is located N-terminally to the catalytic kinase domain (SH1) where it mediates cellular localization, substrate recruitment, a...

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Identifiers

PMID: 19926274
DOI: 10.1016/j.sbi.2009.10.001
PMCID: PMC2791838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19926274-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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