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Article

Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP

15 Jun 2001

Abstract excerpt

X-linked lymphoproliferative disease (XLP) is a rare immune disorder commonly triggered by infection with Epstein-Barr virus. Major disease manifestations include fatal acute infectious mononucleosis, B-cell lymphoma, and progressive dys-gammaglobulinemia. SAP/SH2D1A, the product of the gene mutated in XLP, is a small protein that comprises a single SH2 domain and a short tail of 26 amino acids. SAP binds to a...

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PMID: 11389028
DOI: 10.1182/blood.v97.12.3867

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Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAPPMID 11389028Read ↗

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X-linked lymphoproliferative disease is caused by deficiency of a novel SH2 domain-containing signal transduction adaptor protein.Semantic proximity Read ↗

SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients.Semantic proximity Read ↗

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