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Article

AP ‐1 is involved in ICOS gene expression downstream of TCR / CD 28 and cytokine receptor signaling

14 May 2012

Abstract excerpt

It has been proposed that sustained ICOS expression in chronic inflammatory immune conditions, such as autoimmunity and allergy, contributes to symptom exacerbation. Therefore modulation of ICOS gene expression could be a potential therapeutic strategy for such immune diseases. However, the precise molecular mechanisms controlling ICOS gene expression remain poorly understood. In this study, we explored...

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PMID: 22585681
DOI: 10.1002/eji.201141897

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