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Article

Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

29 Oct 2018

Abstract excerpt

Activation of platelet-derived growth factor receptor alpha (PDGFRA) by genomic aberrations contributes to tumor progression in several tumor types. In this study, we characterize 16 novel PDGFRA mutations identified from different tumor types and identify three previously uncharacterized activating mutations that promote cell survival and proliferation. PDGFRA Y288C, an extracellular domain mutation, is...

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PMID: 30389923
DOI: 10.1038/s41467-018-06949-w

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