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Article

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.

The EMBO journal - 4 Aug 2004

Fang Yanan, Tsao Cheng-Chung, Goodman Barbara K, Furumai Ryohei, Tirado Carlos A, Abraham Robert T, Wang Xiao-Fan

Abstract excerpt

The ataxia-telangiectasia mutated and rad3-related (ATR) kinase orchestrates cellular responses to DNA damage and replication stress. Complete loss of ATR function leads to chromosomal instability and cell death. However, heterozygous ATR mutations are found in human cancers with microsatellite instability, suggesting that ATR haploinsufficiency contributes to tumorigenesis. To test this possibility, we generated...

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15282542
DOI: 10.1038/sj.emboj.7600315
PMCID: PMC514932

Genes

ATR
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.PMID 15282542Read ↗

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Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance.Semantic proximity Read ↗

Mutations in DNA mismatch repair genes: implications for DNA damage signaling and drug sensitivity (review).Semantic proximity Read ↗

Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.Semantic proximity Read ↗

ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damageSemantic proximity Read ↗

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivitySemantic proximity Read ↗

An MLH1 mutation links BACH1/FANCJ to colon cancer, signaling, and insight toward directed therapy.Semantic proximity Read ↗

The DNA damage response to ATR inhibitionSemantic proximity Read ↗

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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress.Semantic proximity Read ↗

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapySemantic proximity Read ↗

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